Cytauxzoon felis cytochrome b gene mutation associated with atovaquone and azithromycin treatment
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics of Cytauxzoon felis cytochrome b: implications for atovaquone and azithromycin therapy in domestic cats with cytauxzoonosis.
Cytauxzoon felis, an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&A). Atovaquone targets parasite cytochrome b. We characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats.
متن کاملRapid High-Resolution Melt Analysis of Cytauxzoon felis Cytochrome b To Aid in the Prognosis of Cytauxzoonosis.
Cytauxzoon felis is a virulent, tick-transmitted, protozoan parasite that infects felines. Cytauxzoonosis was previously thought to be uniformly fatal in domestic cats. Treatment combining atovaquone and azithromycin (A&A) has been associated with survival rates of over 60%. Atovaquone, a ubiquinone analogue, targets C. felis cytochrome b (cytb), of which 30 unique genotypes have been identifie...
متن کاملMultiple cytochrome B mutations may cause atovaquone resistance.
Phillips and Lampe [1]. Given the rapid changes in HAART over the past decade— including marked improvements in potency, tolerability, and dosing frequency, it is doubtful that we will ever have an observational cohort in which patients receive the same therapy for 10 years. New therapies are certain to emerge that will be adopted, and the details of the research questions will change over time.
متن کاملTwo Tales of Cytauxzoon felis Infections in Domestic Cats.
Cytauxzoonosis is an emerging infectious disease that affects wild felids as well as the domestic cat; it is caused by the apicomplexan protozoan parasites belonging to the genus Cytauxzoon. Cytauxzoonfelis is the species of major concern, whose transmission occurs via the bite of an infected tick. Cytauxzoonosis of the domestic cat has historically been considered uniformly fatal, with a short...
متن کاملCytauxzoon felis and ‘Candidatus Mycoplasma haemominutum’ coinfection in a Brazilian domestic cat (Felis catus) Co-infecção por Cytauxzoon felis e ‘Candidatus Mycoplasma haemominutum’ em um gato doméstico (Felis catus) no Brasil
This article describes the first detection of Cytauxzoon felis, using molecular techniques, in a naturally infected domestic cat from Brazil, South America. Coinfection with ‘Candidatus Mycoplasma haemominutum’ was also found. The molecular identification of the piroplasmid species was performed by Polymerase Chain Reaction (PCR) and sequencing analysis. A 284 pb fragment of the gene encoding t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2020
ISSN: 0891-6640,1939-1676
DOI: 10.1111/jvim.15935